It will likely still be possible, given that it is a PC game, and its files are so readily accessible to the user, but the level of difficulty to mod will remain to be seen, and the clear disdain for the modding community producing content that SEGA/Relic can't cash in on themselves is practically a declaration of war from them even before the first 'post release' mod gets off the ground.

Now that SEGA owns Relic, it's practically a snake eating its own tail with how much the two entities openly despise the modding community, and I have absolutely no hope of support from official avenues for modding Company of Heroes 2. Ironically, it was modders who actually -=FIXED=- their broken code in Medieval 2 and Empire especially, which SEGA then flagrantly stole and used as their own since they apparently can't pay programmers good enough to compete with the modders working for FREE. Since Empire: Total War especially they have quite purposely released patches and gone to great lengths for no other reason to hamper modding. SEGA, the anti-christ of modding everywhere, has been violently and obviously counter to the modding community since they bought up the Creative Assembly studio, who are responsible for the Total War series. However, to perpetually make it evermore annoying and hard for modders to keep their mods compatible, they continued update after update which were nothing more than statistical adjustments, and yet they purposely re-configured how start-up files were loaded and thus mods as well were directly effected and hindered. Relic themselves have been progressively more and more hostile toward the modding community for many years to the point that on multiple occasions they made COH1 entirely unusable with mods until overwhelming community outcry made them reluctantly relent.

Well this is sadly something I had predicted long before CoH2 was even a distant thought.

Company of heroes 2 cheat mods